Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

نویسندگان

  • Johan G C van Hasselt
  • Natasha K A van Eijkelenburg
  • Alwin D R Huitema
  • Jan H M Schellens
  • Antoinette Y N Schouten-van Meeteren
چکیده

We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 57 6  شماره 

صفحات  -

تاریخ انتشار 2013